Ace the Blood & Immune Challenge 2026 – Conquer Hematologic Hurdles and Boost Your Skills!

Chronic Lymphocytic Leukemia involves a malignant clone that originates from mature B lymphocytes. These abnormal B cells accumulate in the blood and bone marrow and often carry B-cell surface markers, reflecting their lineage. This differentiates CLL from conditions that arise from other cell types, such as T cells (seen in some T-cell leukemias), plasma cells (as in plasma cell myeloma), or erythrocytes (red blood cells, which are not leukocytes). Therefore, the malignant clone in CLL is derived from B lymphocytes.